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Brewers starting pitcher Adrian Houser was still working on a no-hitter when he was pulled in the seventh inning Tuesday night against the Pirates.
The Brewers led 4-0 at the time, eventually losing to Pittsburgh 8-5 in 10 innings.
Gregory Polanco drove in the winning run in extra innings, giving reliever Blaine Hardy the loss.
Milwaukee had just swept a series at Pittsburgh last week.
Avisail Garcia went three-for-five with three runs batted in and Willy Adames hit his 18th home run for the Brewers.
The teams wrap up the three-game series this afternoon with National League E-R-A leader Freddy Peralta starting for Milwaukee.
First pitch on 107.9 FM WOMT is scheduled for 1:10 PM.
