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I-43 Southbound is down to a single lane in Manitowoc after a semi rolled off the highway. The incident occurred just before the Calumet Avenue exit. An ambulance was seen leaving the area, but the condition of the driver is not known at this time. The Manitowoc County Sheriff’s Department is conducting the investigation, but officers from the Manitowoc Police Department were on hand, along with Manitowoc Fire Rescue, Valders Fire Department, and Silver Creek Fire and Rescue.